About the PROBCONS project
PROBCONS is a novel tool for generating multiple alignments of protein
sequences. Using a combination of probabilistic modeling and consistency-based alignment techniques,
PROBCONS has achieved the highest accuracies of all alignment methods
to date. On the BAliBASE benchmark alignment database, alignments produced by
PROBCONS show statistically significant improvement over current
programs, containing an average of 7% more correctly aligned columns than those of T-Coffee,
11% more correctly aligned columns than those of CLUSTAL W, and 14% more correctly aligned columns
than those of DIALIGN.
PROBCONS was developed by Chuong Do in collaboration with Michael Brudno in
the research group of Serafim Batzoglou, Department of Computer Science, Stanford University.
The methods used in PROBCONS are described in the following paper: